InterPro : IPR002345

Name  Lipocalin Short Name  Lipocalin
Type  Family Description  The lipocalins are a diverse, interesting, yet poorly understood family of proteins composed, in the main, of extracellular ligand-binding proteinsdisplaying high specificity for small hydrophobic molecules []. Functionsof these proteins include transport of nutrients, control of cell regulation, pheromone transport, cryptic colouration, and the enzymatic synthesisof prostaglandins.The crystal structures of several lipocalins have been solved and show a novel 8-stranded anti-parallel beta-barrel fold well conserved within thefamily. Sequence similarity within the family is at a much lower level andwould seem to be restricted to conserved disulphides and 3 motifs, whichform a juxtaposed cluster that may act as a common cell surface receptorsite [, ]. By contrast, at the more variable end of the fold are found an internal ligand binding site and a putative surface for the formation of macromolecular complexes []. The anti-parallel beta-barrel fold is alsoexploited by the fatty acid-binding proteins, which function similarly bybinding small hydrophobic molecules. Similarity at the sequence level,however, is less obvious, being confined to a single short N-terminal motif.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

5 Child Features

Id Name Short Name Type
IPR002447 Beta-lactoglobulin Blactoglobulin Family
IPR002971 Major urinary protein Maj_urinary Family
IPR002972 Prostaglandin D synthase PstgldnD_synth Family
IPR002968 Alpha-1-microglobulin A1-microglobln Family
IPR003087 Neutrophil gelatinase-associated lipocalin N_gelatinase Family

3 Contains

Id Name Short Name Type
IPR011038 Calycin-like Calycin-like Domain
IPR012674 Calycin Calycin Domain
IPR022272 Lipocalin family conserved site Lipocalin_CS Conserved_site

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Flower DR Mouse oncogene protein 24p3 is a member of the lipocalin protein family. 1991 Biochem Biophys Res Commun 180 69-74
Flower DR Structure and sequence relationships in the lipocalins and related proteins. 1993 Protein Sci 2 753-61
Flower DR Multiple molecular recognition properties of the lipocalin protein family. 1995 J Mol Recognit 8 185-95
Pervaiz S Homology of beta-lactoglobulin, serum retinol-binding protein, and protein HC. 1985 Science 228 335-7



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)