InterPro : IPR028621

Name  ATP-dependent RNA helicase SrmB Short Name  DEAD_helicase_SrmB
Type  Family Description  RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). SrmB is a DEAD-box RNA helicase that is involved in ribosome assembly. Deletion of the srmB gene in Escherichia coli causes a slow-growth phenotype at low temperature [].
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Proteins

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2 Publications

First Author Title Year Journal Volume Pages
Koonin EV Autogenous translation regulation by Escherichia coli ATPase SecA may be mediated by an intrinsic RNA helicase activity of this protein. 1992 FEBS Lett 298 6-8
Charollais J The DEAD-box RNA helicase SrmB is involved in the assembly of 50S ribosomal subunits in Escherichia coli. 2003 Mol Microbiol 48 1253-65



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)