InterPro : IPR012013

Name  Integrin beta-4 subunit Short Name  Integrin_bsu-4
Type  Family Description  Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. The integrin receptors are composed of alpha and beta subunit heterodimers. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.The beta 4 subunit differs from other beta subunits in three ways: 1) the cytoplasmic domain is larger; 2) it lacks some of the conserved cysteines in the extracellular domain; and 3) it has a unique domain organisation.Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells []. Integrin beta-4 is required for the regulation of keratinocyte polarity and motility [].For additional information please see [, , , , , , , ].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

7 Contains

Id Name Short Name Type
IPR003961 Fibronectin type III FN3_dom Domain
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR002035 von Willebrand factor, type A VWF_A Domain
IPR013111 EGF-like domain, extracellular EGF_extracell Domain
IPR003644 Na-Ca exchanger/integrin-beta4 Calx_beta Domain
IPR002369 Integrin beta subunit, N-terminal Integrin_bsu_N Domain
IPR012896 Integrin beta subunit, tail Integrin_bsu_tail Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR015812 Integrin beta subunit Integrin_bsu Family

15 Publications

First Author Title Year Journal Volume Pages
Hynes RO Integrins: bidirectional, allosteric signaling machines. 2002 Cell 110 673-87
Demetriou MC Integrin clipping: a novel adhesion switch? 2004 J Cell Biochem 91 26-35
Cheresh DA A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells. 1989 Cell 57 59-69
Bökel C Integrins in development: moving on, responding to, and sticking to the extracellular matrix. 2002 Dev Cell 3 311-21
Arnaout MA Integrin structure: new twists and turns in dynamic cell adhesion. 2002 Immunol Rev 186 125-40
Iacovacci S Genomic organization of the human integrin beta4 gene. 1997 Mamm Genome 8 448-50
LaFlamme SE Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus. 1997 Matrix Biol 16 153-63
Hogervorst F Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. 1990 EMBO J 9 765-70
Suzuki S Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. 1990 EMBO J 9 757-63
Kajiji S A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. 1989 EMBO J 8 673-80
Strömblad S Cell adhesion and angiogenesis. 1996 Trends Cell Biol 6 462-8
Tamura RN Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. 1990 J Cell Biol 111 1593-604
Clarke AS A novel structural variant of the human beta 4 integrin cDNA. 1994 Cell Adhes Commun 2 1-6
Koster J Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. 2003 J Cell Sci 116 387-99
Hamill KJ BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities. 2009 Mol Biol Cell 20 2954-62

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)