InterPro : IPR028619

Name  ATP-dependent RNA helicase DbpA Short Name  DEAD_helicase_DbpA
Type  Family Description  RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). The RNA helicase DbpA has an RNA-dependent ATPase activity, which is specific for 23S rRNA [, ]. It is involved in assembly of the 50S ribosomal subunit [].
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4 Publications

First Author Title Year Journal Volume Pages
Koonin EV Autogenous translation regulation by Escherichia coli ATPase SecA may be mediated by an intrinsic RNA helicase activity of this protein. 1992 FEBS Lett 298 6-8
Fuller-Pace FV DbpA: a DEAD box protein specifically activated by 23s rRNA. 1993 EMBO J 12 3619-26
Böddeker N Characterization of DbpA, an Escherichia coli DEAD box protein with ATP independent RNA unwinding activity. 1997 Nucleic Acids Res 25 537-45
Sharpe Elles LM A dominant negative mutant of the E. coli RNA helicase DbpA blocks assembly of the 50S ribosomal subunit. 2009 Nucleic Acids Res 37 6503-14



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)