InterPro : IPR028618

Name  ATP-dependent RNA helicase DeaD Short Name  DEAD_helicase_DeaD
Type  Family Description  RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). The RNA helicase DeaD is ATP-dependent []and is induced by low temperatures []. In addition to its role in unwinding double stranded RNA, it is involved in ribosomal subunit biogenesis [].
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4 Publications

First Author Title Year Journal Volume Pages
Koonin EV Autogenous translation regulation by Escherichia coli ATPase SecA may be mediated by an intrinsic RNA helicase activity of this protein. 1992 FEBS Lett 298 6-8
Jones PG Cold shock induces a major ribosomal-associated protein that unwinds double-stranded RNA in Escherichia coli. 1996 Proc Natl Acad Sci U S A 93 76-80
Toone WM deaD, a new Escherichia coli gene encoding a presumed ATP-dependent RNA helicase, can suppress a mutation in rpsB, the gene encoding ribosomal protein S2. 1991 J Bacteriol 173 3291-302
Charollais J CsdA, a cold-shock RNA helicase from Escherichia coli, is involved in the biogenesis of 50S ribosomal subunit. 2004 Nucleic Acids Res 32 2751-9



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)