InterPro : IPR023067

Name  DNA protection during starvation protein, gammaproteobacteria Short Name  Dps_gammaproteobac
Type  Family Description  This group belongs to the ferritin domain superfamily and has the ferritin-like structural fold. Ferritins constitute a broad superfamily of iron storage proteins, widespread in all domains of life [, ]. Ferritins and bacterioferritins have essentially the same architecture, assembling in a 24mer cluster to form a hollow, roughly spherical, construction. This consists of a mineral core of hydrated ferric oxide and a multi-subunit protein shell, which encloses the former and assures its solubility in an aqueous environment. Due to the absence of the C-terminal fifth helix of 24mer ferritins, members of the Dps group assemble only to dodecameric protein shells [].Members of this entry were originally discovered as stress proteins, which protect DNA against oxidative stress during nutrient starvation [], hence the name Dps (DNA protection during starvation protein). Several members of the group, such as Dps from Escherichia coli, exhibit a DNA-binding activity that is at least partially linked with iron complexation []. DNA binding by these proteins was shown to suffice for protection against oxidative DNA damage and might be mediated by magnesium ions, which bridge the protein surfaces with the polyanionic DNA [, ]. Dps also contributes to defense against copper stress in growing cells of E. coli [].
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

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0 Found In

1 Parent Features

Id Name Short Name Type
IPR002177 DNA-binding protein Dps DPS_DNA-bd Family

7 Publications

First Author Title Year Journal Volume Pages
Almirón M A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli. 1992 Genes Dev 6 2646-54
Frenkiel-Krispin D Regulated phase transitions of bacterial chromatin: a non-enzymatic pathway for generic DNA protection. 2001 EMBO J 20 1184-91
Zeth K Iron-oxo clusters biomineralizing on protein surfaces: structural analysis of Halobacterium salinarum DpsA in its low- and high-iron states. 2004 Proc Natl Acad Sci U S A 101 13780-5
Carrondo MA Ferritins, iron uptake and storage from the bacterioferritin viewpoint. 2003 EMBO J 22 1959-68
Wolf SG DNA protection by stress-induced biocrystallization. 1999 Nature 400 83-5
Theil EC Ferritin: at the crossroads of iron and oxygen metabolism. 2003 J Nutr 133 1549S-53S
Thieme D The Dps protein of Escherichia coli is involved in copper homeostasis. 2010 Microbiol Res 165 108-15



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)