InterPro : IPR018250

Name  Neuregulin Short Name  NRG1
Type  Family Description  Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches [].
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

7 Contains

Id Name Short Name Type
IPR007110 Immunoglobulin-like domain Ig-like_dom Domain
IPR013098 Immunoglobulin I-set Ig_I-set Domain
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR013783 Immunoglobulin-like fold Ig-like_fold Domain
IPR003598 Immunoglobulin subtype 2 Ig_sub2 Domain
IPR002154 Neuregulin 1-related, C-terminal Neuregulin_1_C Domain

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Schroering A Sensory and motor neuron-derived factor is a transmembrane heregulin that is expressed on the plasma membrane with the active domain exposed to the extracellular environment. 1998 J Biol Chem 273 30643-50
Burden S Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. 1997 Neuron 18 847-55
Vartanian T Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. 1999 Proc Natl Acad Sci U S A 96 731-5
Stefansson H Neuregulin 1 and susceptibility to schizophrenia. 2002 Am J Hum Genet 71 877-92



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)