InterPro : IPR004737

Name  Nitrate transporter Short Name  NO3_transporter
Type  Family Description  This family represents nitrate/nitrite antiporters in bacteria, fungi, algae and marine diatoms. Nitrate transporters in Escherichia coliare involved in excretion of nitrite produced by the dissimilatory reduction of nitrate. NarK is polytopic membrane protein with 12 transmembrane domains which is involved in nitrate uptake and nitrite excretion and is thought to function as a nitrate/nitrite antiporter [, ]. At low concentrations of nitrate, NarK mediates the electrogenic excretion of nitrite rather than nitrate/nitrite exchange. This process prevents intracellular accumulation of toxic levels of nitrite and allows further detoxification in the periplasm through the action of nitrite reductase [].In the opportunistic fungal pathogen Aspergillus fumigatusthe nitrate transporter crnA clusters with nitrite reductase (niiA) and nitrate reductase (niaD). NiaD, niiA and crnA are induced by nitrate and repressed by ammonium at the transcriptional level []. In Hebeloma cylindrosporumthe nitrate transporter polypeptide (NRT2) is characterised by 12 transmembrane domains and presents both a long putative intracellular loop and a short C-terminal tail, two structural features which distinguish fungal high-affinity transporters from their plant homologues. Transcription is repressed by ammonium and strongly stimulated by nitrate but also by organic nitrogen or nitrogen deficiency.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR011701 Major facilitator superfamily MFS Family

4 Publications

First Author Title Year Journal Volume Pages
Rowe JJ NarK is a nitrite-extrusion system involved in anaerobic nitrate respiration by Escherichia coli. 1994 Mol Microbiol 12 579-86
Amaar YG Mapping of the nitrate-assimilation gene cluster (crnA-niiA-niaD) and characterization of the nitrite reductase gene (niiA) in the opportunistic fungal pathogen Aspergillus fumigatus. 1998 Curr Genet 33 206-15
Jia W A single channel for nitrate uptake, nitrite export and nitrite uptake by Escherichia coli NarU and a role for NirC in nitrite export and uptake. 2009 Biochem J 417 297-304
Sharma V Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1. 2006 Appl Environ Microbiol 72 695-701

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)