InterPro : IPR004727

Name  Calcium-activated chloride channel protein Short Name  CaCC_prot
Type  Family Description  This entry represents a family of Ca(2+)-regulated chloride channels (CLCA) which includes bovine, murine and human proteins [, ]. Each CLCA exhibits a distinct, often overlapping, tissue expression pattern. With the exception of the truncated, secreted protein hCLCA3 [], they are synthesized as an approximately 125 kDa precursor transmembrane glycoprotein that is rapidly cleaved into 90 and 35 kDa subunits. The human proteins have been shown to affect a large number of cell functions including chloride conductance, epithelial secretion, cell-cell adhesion, apoptosis, cell cycle control, mucus production in asthma, and blood pressure. The CLCA proteins expressed on the luminal surface of lung vascular endothelia (bCLCA2; mCLCA1; hCLCA2) serve as adhesion molecules for lung metastatic cancer cells, mediating vascular arrest and lung colonization. Expression of hCLCA2 in normal mammary epithelium is consistently lost in human breast cancer and in all tumorigenic breast cancer cell lines. Re-expression of hCLCA2 in human breast cancer cells abrogates tumorigenicity in nude mice, implying that hCLCA2 acts as a tumour suppressor in breast cancer.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR002035 von Willebrand factor, type A VWF_A Domain
IPR013642 Chloride channel calcium-activated Cl_channel_Ca Domain
IPR015394 Domain of unknown function DUF1973 DUF1973 Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Pauli BU Molecular characteristics and functional diversity of CLCA family members. 2000 Clin Exp Pharmacol Physiol 27 901-5
Loewen ME Structure and function of CLCA proteins. 2005 Physiol Rev 85 1061-92
Gruber AD Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels. 1999 Biochim Biophys Acta 1444 418-23

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)