InterPro : IPR016481

Name  Transcription factor TFE, archaea Short Name  TF_E_archaea
Type  Family Description  Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit () and the small beta (). TFIIE beta has been found to bind to the region where the promoter starts to open to be single-stranded upon transcription initiation by RNA polymerase II. The approximately 120-residue central core domain of TFIIE beta plays a role in double-stranded DNA binding of TFIIE [].The TFIIE beta central core DNA-binding domain consists of three helices with a beta hairpin at the C terminus, resembling the winged helix proteins. It shows a novel double-stranded DNA-binding activity where the DNA-binding surface locates on the opposite side to the previously reported winged helix motif by forming a positively charged furrow [].Archaea contain a TFIIE homolog, called TFE, which corresponds to the N-terminal half of TFIIEalpha. It appears that archaeal TFE corresponds to the minimal essential region of eukaryotic TFIIEalpha. In archaea TFE contains an N-terminal, weakly conserved, helix-turn-helix (HTH) motif within a leucine-rich region and a C-terminal zinc ribbon [, , ]. It has been proposed that the TFE/IIEalpha-type HTH domain acts as a bridging factor or adapter between the TATA box-binding protein, the polymerase, and possibly promoter DNA [].This entry represents archaeal TFE.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR017919 Transcription factor TFE/TFIIEalpha HTH domain TFIIE/TFIIEa_HTH Domain

0 Found In

0 Parent Features

5 Publications

First Author Title Year Journal Volume Pages
Okuda M Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface. 2000 EMBO J 19 1346-56
Kuldell NH Genetic analysis of the large subunit of yeast transcription factor IIE reveals two regions with distinct functions. 1997 Mol Cell Biol 17 5288-98
Bell SD The archaeal TFIIEalpha homologue facilitates transcription initiation by enhancing TATA-box recognition. 2001 EMBO Rep 2 133-8
Hanzelka BL TFE, an archaeal transcription factor in Methanobacterium thermoautotrophicum related to eucaryal transcription factor TFIIEalpha. 2001 J Bacteriol 183 1813-8
Pastorelli R Effect of butylated hydroxyanisole on the metabolism of N-nitrosodi-n-butylamine and N-nitrosobutyl(4-hydroxybutyl)amine by rat hepatic S9 preparations in vitro. 1987 IARC Sci Publ   183-4

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)