InterPro : IPR016461

Name  O-methyltransferase COMT-type Short Name  O-MeTrfase_COMT
Type  Family Description  This entry represents a family of methyltransferases that includes caffeate O-methyltransferases (), isoflavone-7-O-methyltransferases () and inositol 4-methyltransferases (). Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR014088 C-20 methyltransferase CrtF-related C20_MeTrfase_CrtF Family

3 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain
IPR001077 O-methyltransferase, family 2 O_MeTrfase_2 Domain
IPR012967 Plant methyltransferase dimerisation Plant_MeTrfase_dimerisation Domain

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Schluckebier G Universal catalytic domain structure of AdoMet-dependent methyltransferases. 1995 J Mol Biol 247 16-20
Schubert HL Many paths to methyltransfer: a chronicle of convergence. 2003 Trends Biochem Sci 28 329-35
Kozbial PZ Natural history of S-adenosylmethionine-binding proteins. 2005 BMC Struct Biol 5 19
Wlodarski T Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome. 2011 PLoS One 6 e23168

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)