InterPro : IPR020918

Name  Peptide chain release factor aRF1 Short Name  Peptide_chain-rel_aRF1
Type  Family Description  Terminating protein synthesis on the ribosome requires the presence of a class I polypeptide chain release factor (RF) to induce peptidyl-tRNA hydrolysis. Bacteria possess two class I RFs; RF1 which recognises UAG and UAA, and RF2 which recognises UGA and UAA. Mitochondrial RFs are related structurally and functionally to those of bacteria. Eukaryotes posses only a single class 1 factor, eRF1, which recognises all three termination codons. Similarly, in all archaeal species where the complete sequence of the genome is available, only a single class I factor, aRF1, has been identified so far. The aRF1 family is highly homologous to the eRF1 family, indicating a common origin and ancestor molecule. The bacterial and mitochondrial class I RFs show no significant sequence similarity with their eukaryotic and archaeal counterparts and are considered to form a separate family. For more information see [, , ].This entry represents the archaeal release factor aRF1.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR005142 eRF1 domain 3 eRF1_3 Domain
IPR005141 eRF1 domain 2 eRF1_2 Domain
IPR005140 eRF1 domain 1/Pelota-like eRF1_1_Pelota Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR004403 Peptide chain release factor eRF1/aRF1 Peptide_chain-rel_eRF1/aRF1 Family

3 Publications

First Author Title Year Journal Volume Pages
Buckingham RH Polypeptide chain release factors. 1997 Mol Microbiol 24 449-56
Dontsova M Translation termination factor aRF1 from the archaeon Methanococcus jannaschii is active with eukaryotic ribosomes. 2000 FEBS Lett 472 213-6
Karamyshev AL Polypeptide release factor eRF1 from Tetrahymena thermophila: cDNA cloning, purification and complex formation with yeast eRF3. 1999 FEBS Lett 457 483-8

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)