InterPro : IPR003356

Name  DNA methylase, adenine-specific Short Name  DNA_methylase_A-5
Type  Domain Description  This domain is fpound in N-6 adenine-specific DNA methylase () from Type I and Type IC restriction systems.These enzymes are responsible for the methylation of specific DNA sequences in order to prevent the host from digesting its own genome via its restriction enzymes. These methylases have the same sequence specificity as their corresponding restriction enzymes. The type I restriction and modification system is composed of three polypeptides R, M and S. The M and S subunits together form a methyltransferase that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit, the complex can also act as an endonuclease, binding to the same target sequence but cutting the DNA some distance from this site. Whether the DNA is cut or modified depends on the methylation state of the target sequence. When the target site is unmodified, the DNA is cut. When the target site is hemimethylated, the complex acts as a maintenance methyltransferase, modifying the DNA so that both strands become methylated.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR002052 DNA methylase, N-6 adenine-specific, conserved site DNA_methylase_N6_adenine_CS Conserved_site

3 Found In

Id Name Short Name Type
IPR002296 N6 adenine-specific DNA methyltransferase, N12 class N12N6_MeTrfase Family
IPR004546 Restriction endonuclease, type I, HsdM Restrct_endonuc_typeI_HsdM Family
IPR016843 S-adenosyl-L-methionine dependent adenine methyltransferase, bacteria, predicted S-AdoMet-dep_Ade-MeTrfase_prd Family

0 Parent Features

0 Publications

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)