InterPro : IPR004517

Name  ATP phosphoribosyltransferase regulatory subunit Short Name  HisZ
Type  Family Description  Protein in this entry are mostly annotated as the ATP phosphoribosyltransferase regulatory subunit (HisZ). However, this entry also includes some histidine-tRNA ligases (HisS or HisRS), which is the paralogue of HisZ. Despite the significant sequential and structural similarity, HisRS and HisZ have different functions []. HisRS is a class IIa aminoacyl-tRNA synthetase (ligase), while HisZ is a regulatory subunit of the hetero-octameric ATP phosphoribosyl transferase that regulate reactions initiating histidine biosynthesis [, ]. From the phylogenetic analysis, HisZ proteins form a monophyletic group that attaches outside the predominant bacterial HisRS clade []. HisZ are represented in a highly divergent set of bacteria (including an aquificale, cyanobacteria, firmicutes, and proteobacteria), but are missing from other bacteria, including mycrobacteria and certain proteobacteria []. It has been suggested that the absences of HisZ from bacteria are due to its loss during evolution [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain aa-tRNA-synt_IIb_cons-dom Domain
IPR006195 Aminoacyl-tRNA synthetase, class II aa-tRNA-synth_II Domain

0 Found In

1 Parent Features

Id Name Short Name Type
IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit HisRS/HisZ Family

4 Publications

First Author Title Year Journal Volume Pages
Vega MC Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. 2005 Mol Microbiol 55 675-86
Champagne KS Activation of the hetero-octameric ATP phosphoribosyl transferase through subunit interface rearrangement by a tRNA synthetase paralog. 2005 J Biol Chem 280 34096-104
Merritt EA Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. 2010 J Mol Biol 397 481-94
Bond JP Proteobacterial histidine-biosynthetic pathways are paraphyletic. 2000 J Mol Evol 50 339-47

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)