InterPro : IPR016279

Name  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma Short Name  PLC-gamma
Type  Family Description  This group represents a 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma. Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



2 Child Features

Id Name Short Name Type
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLC-gamma2 Family
IPR028380 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 PLC-gamma1 Family

10 Contains

Id Name Short Name Type
IPR000008 C2 domain C2_dom Domain
IPR001452 SH3 domain SH3_domain Domain
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR000980 SH2 domain SH2 Domain
IPR001849 Pleckstrin homology domain PH_domain Domain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain PLC-like_Pdiesterase_TIM-brl Domain
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain PLipase_C_PInositol-sp_X_dom Domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain PLipase_C_Pinositol-sp_Y Domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like PLipase_C_EF-hand-like Domain
IPR018247 EF-Hand 1, calcium-binding site EF_Hand_1_Ca_BS Binding_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR001192 Phosphoinositide phospholipase C family PI-PLC_fam Family

2 Publications

First Author Title Year Journal Volume Pages
Wilde JI Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other? 2001 Cell Signal 13 691-701
Gresset A Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes. 2010 J Biol Chem 285 35836-47

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)