InterPro : IPR014285

Name  Nitrogen fixation negative regulator NifL Short Name  N_fixation_neg-reg_NifL
Type  Family Description  NifL from Azotobacter vinelandiisenses both the redox and fixed nitrogen status to regulate nitrogen fixation. NifL acts by modulating the activity of the nitrogen fixation positive regulator protein NifA: NifL inhibits NifA in response to oxygen and low level of fixed nitrogen. NifA and NifL are encoded by adjacent genes. NifL is FAD-containing, and has a domain architecture similar to that of the cytoplasmic histidine protein kinases, containing two N-terminal PAS domains and a C-terminal transmitter region containing a conserved histidine residue (H domain) and a nucleotide binding GHKL domain corresponding to the catalytic core of the histidine kinases []. However, NifL does not exhibit kinase activity and regulates its partner NifA by direct protein-protein interactions rather than phosphorylation.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

6 Contains

Id Name Short Name Type
IPR003594 Histidine kinase-like ATPase, C-terminal domain HATPase_C Domain
IPR000014 PAS domain PAS Domain
IPR013767 PAS fold PAS_fold Domain
IPR001610 PAC motif PAC Repeat
IPR000700 PAS-associated, C-terminal PAS-assoc_C Domain
IPR004358 Signal transduction histidine kinase-related protein, C-terminal Sig_transdc_His_kin-like_C Domain

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Little R Role of the H domain of the histidine kinase-like protein NifL in signal transmission. 2007 J Biol Chem 282 13429-37

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)