InterPro : IPR029773

Name  Melanotransferrin Short Name  MTF
Type  Family Description  Melanotransferrin (MTF, also known as p97) belongs to the transferrin family, which is a group of iron-binding proteins that control the level of free iron in biological fluids []. p97 has two forms, the soluble form and the isoform that is attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor [,]. The soluble form has the ability to traverse the blood-brain barrier and may be used to deliver drugs into the brain, while the GPI-linked form plays a role in the uptake of iron [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR016357 Transferrin Transferrin Family

3 Publications

First Author Title Year Journal Volume Pages
Crichton RR Iron transport and storage. 1987 Eur J Biochem 164 485-506
Yang J Deletion of the GPI pre-anchor sequence in human p97--a general approach for generating the soluble form of GPI-linked proteins. 2004 Protein Expr Purif 34 28-48
Kennard ML A novel iron uptake mechanism mediated by GPI-anchored human p97. 1995 EMBO J 14 4178-86

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)