InterPro : IPR028331

Name  Probable ATP-dependent RNA helicase DDX11/DDX12 Short Name  DDX11/DDX12
Type  Family Description  DDX11 is the mammalian homologue of the yeast CHL1. DDX11 is a DNA helicase involved in cellular proliferation []. In humans a second homologue has been identified, DDX12 []. DDX11 translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent, dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplex structures do not support unwinding []. Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS), a syndrome characterised by severe microcephaly, growth retardation, facial dysmorphism and abnormal skin pigmentation [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

1 Parent Features

Id Name Short Name Type
IPR013020 DNA helicase (DNA repair), Rad3 type DNA_helicase_DNA-repair_Rad3 Family

4 Publications

First Author Title Year Journal Volume Pages
Inoue A Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. 2007 Cell Cycle 6 1646-54
van der Lelij P Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. 2010 Am J Hum Genet 86 262-6
Hirota Y Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. 2000 Nucleic Acids Res 28 917-24
Amann J Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. 1997 J Biol Chem 272 3823-32

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)