InterPro : IPR017298

Name  Transcriptional regulator Ure2 Short Name  Ure2
Type  Family Description  Ure2 is a yeast transcriptional regulator that plays an important role in the regulation of nitrogen metabolism []. When easily utilised nitrogen sources are present, yeast cells down-regulate the synthesis of proteins involved in utilising poor nitrogen sources. Ure2 assists this process by interacting with, and repressing, the transcription factor Gln3, repressing the transcription of these proteins. Ure2 exists in two forms; a functional form and an infectious, non-functional prion form. Structurally, Ure2 is a homodimer where each monomer has a globular C-terminal region, and a poorly structured N-terminal region [, ]. The globular region, which is sufficient for its regulatory activity, forms a glutathione-S-transferase-like fold. The N-termnial region is known as the prion region and may interact with the globular region to prevent the protein from converting into its prion form.
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Sequence Features

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Proteins

InterPro protein domain ID --> Contigs

 

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0 Child Features

2 Contains

Id Name Short Name Type
IPR004046 Glutathione S-transferase, C-terminal GST_C Domain
IPR004045 Glutathione S-transferase, N-terminal Glutathione_S-Trfase_N Domain

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3 Publications

First Author Title Year Journal Volume Pages
Bousset L Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae. 2001 Structure 9 39-46
Coschigano PW The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases. 1991 Mol Cell Biol 11 822-32
Edskes HK Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein. 2002 Proc Natl Acad Sci U S A 99 Suppl 4 16384-91



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)