InterPro : IPR010043

Name  Protein-PII uridylyltransferase Short Name  GlnD_Uridyltrans
Type  Family Description  This entry describes GlnD, the uridylyltransferase/uridylyl-removing enzyme for signal-transduction protein PII, and acts as the sensory component of the nitrogen regulation (ntr) system [, ]. The ntr system modulates nitrogen metabolism in response to the prevailing nitrogen source and the requirements of the cell. During nitrogen fixation, ammonia and 2-oxoglutarate can be used to produce glutamate. The activity of the PII protein is stimulated by glutamine and inhibited by 2-oxoglutarate. Under glutamate-limiting conditions, PII is uridylylated by GlnD leading to the activation of glutamate synthetase and to the stimulation of NtrC-dependent promoters. Under high concentrations of fixed nitrogen, PII is de-uridylylated leading to the inactivation of the glutamate synthetase pathway and switching off NtrC-dependent promoters [].Not all homologues of PII share the property of uridylyltransferase modification on the characteristic Tyr residue (see ), but the modification site is preserved in the PII homologue of all species with a member of this family.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

5 Contains

Id Name Short Name Type
IPR006674 HD domain HD_domain Domain
IPR002934 Nucleotidyl transferase domain Nucleotidyltransferase Domain
IPR003607 HD/PDEase domain HD/PDEase_dom Domain
IPR002912 ACT domain ACT_dom Domain
IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase PII_UdlTrfase/GS_AdlTrfase Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Garcia E Cascade control of Escherichia coli glutamine synthetase. Purification and properties of PII uridylyltransferase and uridylyl-removing enzyme. 1983 J Biol Chem 258 2246-53
Schlüter A The Rhizobium leguminosarum bv. viciae glnD gene, encoding a uridylyltransferase/uridylyl-removing enzyme, is expressed in the root nodule but is not essential for nitrogen fixation. 2000 Microbiology 146 ( Pt 11) 2987-96
Van Dommelen A Cloning and characterisation of the Azospirillum brasilense glnD gene and analysis of a glnD mutant. 2002 Mol Genet Genomics 266 813-20

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)