InterPro : IPR006261

Name  Deoxyguanosinetriphosphate triphosphohydrolase Short Name  dGTP_triP_hydro
Type  Family Description  Deoxyguanosine triphosphate triphosphohydrolase (dGTPase) releases inorganic triphosphate, an unusual reaction product, from GTP []. dGTPase preferentially hydrolyses dGTP over the other canonical NTPs []. It has been suggested that its activity is limited to the Enterobacteriaceae [], although homologous sequences are detected elsewhere []. This finding casts doubt on whether the activity is shared in other species. In several of these other species, the homologous gene is found in an apparent operon with dnaG, the DNA primase gene. The enzyme from Escherichia coliwas shown to bind cooperatively to single stranded DNA.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



3 Child Features

Id Name Short Name Type
IPR020779 Deoxyguanosinetriphosphate triphosphohydrolase, proteobacteria dGTP_triP_hydro_proteobacteria Family
IPR023023 Deoxyguanosinetriphosphate triphosphohydrolase, type 2 dGTP_triP_hydro_type2 Family
IPR023024 Deoxyguanosinetriphosphate triphosphohydrolase, type 3 dGTP_triP_hydro_type3 Family

2 Contains

Id Name Short Name Type
IPR006674 HD domain HD_domain Domain
IPR003607 HD/PDEase domain HD/PDEase_dom Domain

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Klann AG Characterization of the dnaG locus in Mycobacterium smegmatis reveals linkage of DNA replication and cell division. 1998 J Bacteriol 180 65-72
KORNBERG SR Enzymatic cleavage of deoxyguanosine triphosphate to deoxyguanosine and tripolyphosphate. 1958 J Biol Chem 233 159-62
Seto D The purification and properties of deoxyguanosine triphosphate triphosphohydrolase from Escherichia coli. 1988 J Biol Chem 263 1494-9
Quirk S dGTP triphosphohydrolase, a unique enzyme confined to members of the family Enterobacteriaceae. 1991 J Bacteriol 173 6665-9

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)