InterPro : IPR011284

Name  3-oxoacyl-(acyl-carrier-protein) reductase Short Name  3oxo_ACP_reduc
Type  Family Description  This entry represents 3-oxoacyl-[ACP]reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis found in many plant and bacterial species. This enzyme is involved in type II fatty acid biosynthesis, where the individual metabolic transformations are carried out by different enzymes rather than by a single enzyme as occurs in type I fatty acid biosynthesis [].Structural studies show that the enzyme is a tetramer which forms a typical Rossman fold [, ]. Unlike other members of the short-chain dehydrogenase/reductase superfamily, the enzyme undergoes a marked conformational change upon binding of the NADP(H)cofactor. This conformational change aligns the side chains of the catalytic triad at the active site in an active conformation and increases the affinity of the enzyme for its substrate.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

2 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site Sc_DH/Rdtase_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR002347 Glucose/ribitol dehydrogenase Glc/ribitol_DH Family

3 Publications

First Author Title Year Journal Volume Pages
Price AC Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis. 2001 Biochemistry 40 12772-81
Campbell JW Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. 2001 Annu Rev Microbiol 55 305-32
Wickramasinghe SR Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis. 2006 Biochem J 393 447-57



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)