InterPro : IPR015845

Name  Agropine synthesis reductase Short Name  Mas1
Type  Family Description  Several agrobacteria cause neoplastic diseases in plants, including crown gall disease (Agrobacterium tumefaciens) and hairy root disease (Agrobacterium rhizogenes). The mechanism involves transfer via infective plasmids and subsequent expression of both oncogenes and genes for the synthesis of opines, which can be specifically used as nutrients by the invading bacteria []. Opines are low molecular weight amino acid and sugar phosphate derivatives, e.g., octopine, agropine, and mannopine. The proteins in this group are products of the mas1genes (and homologues) encoding the reductase that produces mannopine from deoxyfructosylglutamine. Subsequently, mannopine can be lactonized to form agropine. The C-terminal short chain dehydrogenase domain () is coupled with an N-terminal phosphoglycerate mutase family domain (), the role of which is unknown []. Sequences reported from Ti plasmid pTiC58 are missing half [, ]or all of the N-terminal domain.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

2 Contains

Id Name Short Name Type
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR020904 Short-chain dehydrogenase/reductase, conserved site Sc_DH/Rdtase_CS Conserved_site

0 Found In

1 Parent Features

Id Name Short Name Type
IPR013078 Histidine phosphatase superfamily, clade-1 His_Pase_superF_clade-1 Family

4 Publications

First Author Title Year Journal Volume Pages
Goodner B Genome sequence of the plant pathogen and biotechnology agent Agrobacterium tumefaciens C58. 2001 Science 294 2323-8
Wood DW The genome of the natural genetic engineer Agrobacterium tumefaciens C58. 2001 Science 294 2317-23
Escobar MA Agrobacterium tumefaciens as an agent of disease. 2003 Trends Plant Sci 8 380-6
Hansen G Agrobacterium rhizogenes pRi8196 T-DNA: mapping and DNA sequence of functions involved in mannopine synthesis and hairy root differentiation. 1991 Proc Natl Acad Sci U S A 88 7763-7

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)