InterPro : IPR017094

Name  Biliverdin reductase A Short Name  Biliverdin_Rdtase_A
Type  Family Description  This entry represents biliverdin reductase A enzymes (), reduces biliverdin (the product of haem oxygenases HO-1 and HO-2 activity) to the antioxidant bilirubin. It works by catalysing the reduction of the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. This reaction is involved in the protohaem degradation pathway as part of porphyrin metabolism. Some enzymes are thought to use zinc as a cofactor. Human biliverdin reductase may also functions as a kinase and as a transcription factorin the MAPK (mitogen-activated protein kinase) signalling cascade [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

3 Contains

Id Name Short Name Type
IPR000683 Oxidoreductase, N-terminal Oxidoreductase_N Domain
IPR016040 NAD(P)-binding domain NAD(P)-bd_dom Domain
IPR015249 Biliverdin reductase, catalytic Biliverdin_Rdtase_cat Domain

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Tudor C Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin. 2008 Biochem J 413 405-16

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)