InterPro : IPR017053

Name  Response regulator, plant B-type Short Name  Response_reg_B-typ_pln
Type  Family Description  Members of this group are plant response regulators of the B type. B-type plant response regulators most closely resemble the classical microbial response regulators.Classical two-component signal transduction systems--consisting of a histidine protein kinase (HK) to sense signal input and a response regulator (RR) to mediate output--are widespread in prokaryotes. Their counterparts are also found in eukaryotes, indicating that they represent an ancient and evolutionarily conserved signalling mechanism. In plants, two-component systems are involved in phytohormone, stress, and light signalling [, ]. Plant response regulators (called ARRs in Arabidopsis thaliana(Mouse-ear cress)) fall into three distinct families based on domain architecture: A-type RRs are stand-alone receiver domains and, therefore, belong to (a large family of signal transduction receiver (phosphoacceptor) proteins, CheY-like), subfamily ; B-type RRs contain an N-terminal receiver domain fused to a Myb-like DNA-binding domain and a variable C-terminal domain; pseudo-response regulators () contain an atypical receiver domain.The classical microbial RRs consist of an N-terminal CheY-like receiver (phosphoacceptor) domain and a C-terminal output (usually DNA-binding) domain. In a typical microbial signal transduction system, in response to an environmental stimulus, a phosphoryl group is transferred from the His residue of sensor histidine kinase to an Asp residue in the CheY-like receiver domain of the cognate response regulator [, , ]. Phosphorylation of the receiver domain induces conformational changes that activate an associated output domain, which in turn triggers the response. Phosphorylation-induced conformational changes in response regulator molecules have been demonstrated in direct structural studies []. For more information on the receiver domain, please see and related groups.The output domain of B-type plant RRs is a central Myb-like DNA-binding domain (with the B, or GARP, motif) [, , ]which is not found in two-component prokaryotic systems. This domain is believed to be responsible for the promoter-binding and transcription factor activity of the B-type plant RRs [, ]. The B motif contains a helix-turn-helix structure and a potential nuclear localization signal, and is considered to be a multifunctional domain responsible for both nuclear localization and DNA binding [].A variable C-terminal domain may also play a role as part of the output module and provides the basis for defining several small subgroups. The functions of these unique C-terminal domains and biological significance of the subgroups are unclear.
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Sequence Features

GO Displayer

Proteins

InterPro protein domain ID --> Contigs

 

Other

0 Child Features

3 Contains

Id Name Short Name Type
IPR017930 Myb domain Myb_dom Domain
IPR001789 Signal transduction response regulator, receiver domain Sig_transdc_resp-reg_receiver Domain
IPR006447 Myb domain, plants Myb_dom_plants Domain

0 Found In

0 Parent Features

9 Publications

First Author Title Year Journal Volume Pages
Stock AM Two-component signal transduction. 2000 Annu Rev Biochem 69 183-215
West AH Histidine kinases and response regulator proteins in two-component signaling systems. 2001 Trends Biochem Sci 26 369-76
Kern D Structure of a transiently phosphorylated switch in bacterial signal transduction. 1999 Nature 402 894-8
Grebe TW The histidine protein kinase superfamily. 1999 Adv Microb Physiol 41 139-227
Hosoda K Molecular structure of the GARP family of plant Myb-related DNA binding motifs of the Arabidopsis response regulators. 2002 Plant Cell 14 2015-29
Lohrmann J The response regulator ARR2: a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial complex I in Arabidopsis. 2001 Mol Genet Genomics 265 2-13
Sakai H Arabidopsis ARR1 and ARR2 response regulators operate as transcriptional activators. 2000 Plant J 24 703-11
Tajima Y Comparative studies on the type-B response regulators revealing their distinctive properties in the His-to-Asp phosphorelay signal transduction of Arabidopsis thaliana. 2004 Plant Cell Physiol 45 28-39
Hwang I Two-component signal transduction pathways in Arabidopsis. 2002 Plant Physiol 129 500-15



To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)