InterPro : IPR006417

Name  Nicotinamide-nucleotide adenylyltransferase Short Name  NadR_NMN_Atrans
Type  Domain Description  The NadR protein of Escherichia coliand closely related bacteria is both enzyme and regulatory protein. The first 60 or so amino acids, N-terminal region is a DNA-binding helix-turn-helix domain () responsible for repressing the nadAB genes of NAD de novo biosynthesis. The NadR homologues in Mycobacterium tuberculosis, Haemophilus influenzae, amongst others, appear to lack the repressor domain. NadR has recently been shown to act as an enzyme of the salvage pathway of NAD biosynthesis, nicotinamide-nucleotide adenylyltransferase; members of this family are presumed to share this activity. E. coli NadR has also been found to regulate the import of its substrate, nicotinamide ribonucleotide, but it is not known if the other members of this family share that activity.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

1 Contains

Id Name Short Name Type
IPR004821 Cytidyltransferase-like domain Cyt_trans-like Domain

1 Found In

Id Name Short Name Type
IPR016429 Bifunctional transcriptional regulator NadR Bifunc_transcrip_reg_NadR Family

0 Parent Features

0 Publications

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)