InterPro : IPR018394

Name  Cryptochrome/DNA photolyase, class 1 conserved site, C-terminal Short Name  DNA_photolyase_1_CS_C
Type  Conserved_site Description  Deoxyribodipyrimidine photolyase (DNA photolyase) []is a DNArepair enzyme. It binds to UV-damaged DNA containing pyrimidine dimers and, upon absorbing a near-UV photon (300 to 500 nm), breaks the cyclobutane ring joining the two pyrimidines of the dimer. DNA photolyase is an enzyme that requires two choromophore-cofactors for its activity: a reduced FADH2 and either 5,10-methenyltetrahydrofolate (5,10-MTFH) or an oxidized 8-hydroxy-5-deazaflavin (8-HDF) derivative (F420). The folate or deazaflavin chromophore appears to function as an antenna, while the FADH2 chromophore is thought to be responsible for electron transfer.On the basis of sequence similarities DNA photolyases can be grouped into two classes []. The first class contains enzymes from eubacteria, the halophilic archaebacteria Halobacterium salinarium(Halobacterium halobium), fungi and plants. Class 1 enzymes bind either 5,10-MTHF (Escherichia coli, fungi, etc.) or 8-HDF (Streptomyces griseus, Halobacterium halobium) [, ]. The second class contains DNA photolyases from higher eukaryotes, methanobacteria and eubacteria.This family also includes plant cryptochromes 1 (CRY1) and 2 (CRY2),which are blue light photoreceptors that mediate blue light-induced geneexpression.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

4 Found In

Id Name Short Name Type
IPR005101 DNA photolyase, FAD-binding/Cryptochrome, C-terminal Photolyase_FAD-bd/Cryptochr_C Domain
IPR002081 Cryptochrome/DNA photolyase, class 1 Cryptochrome/DNA_photolyase_1 Family
IPR014134 Cryptochrome, plant Cryptochrome_pln Family
IPR019947 Deoxyribodipyrimidine photo-lyase, 8-HDF type Photolyase_8HDF Family

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Jorns MS DNA photorepair: chromophore composition and function in two classes of DNA photolyases. 1990 Biofactors 2 207-11
Yasui A A new class of DNA photolyases present in various organisms including aplacental mammals. 1994 EMBO J 13 6143-51
Kobayashi T Molecular characterization of a gene encoding a photolyase from Streptomyces griseus. 1989 Nucleic Acids Res 17 4731-44
Weber S Light-driven enzymatic catalysis of DNA repair: a review of recent biophysical studies on photolyase. 2005 Biochim Biophys Acta 1707 1-23

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)