InterPro : IPR002396

Name  Selectin superfamily Short Name  Selectin_superfamily
Type  Family Description  Animal lectins display a wide variety of architectures.They are classified according to the carbohydrate-recognitiondomain (CRD) of which there are two main types, S-type and C-type.C-type lectins display a wide range of specificities.They require Ca2+for their activityThey are found predominantly but not exclusively in vertebrates.They can be classified into a number of subgroups based on their function and structure:Endocytic lectins - Membrane-bound receptors that mediate endocytosis of glycoproteinsCollectins -Represented by the soluble mannose-binding proteins of mammalian serum and liver Selectins - Membrane-bound proteins involved in inflammation. There are three main divisions, CD62E, CD62 L and CD62P [].CD62E (also called E-selectin, ELAM-1 or LECAM-2), CD62L (also called L-selectin, LAM-1, LECAM-1, Leu-8, MEL-14 or TQ-1) and CD62P (also called P-selectin, granule membrane protein-140, GMP-140 or platelet activation dependent granule-external membrane protein, PADGEM) belong to this group.CD62E mediates leukocyte rolling on activated endothelium at inflammatory sites and may also support tumor cell adhesion during hematogenous metastasis, and play a role in angiogenesis. CD62L mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue and leukocyte rolling on activated endothelium at inflammatory sites. Interaction of CD62P with PSGL-1 mediates tethering and rolling of leukocytes on the surface of activated endothelial cells,the first step in leukocyte extravasation and migration towards inflammations. CD62P mediates rolling of platelets on endothelial cells and CD62P-mediated interactions are also involved in platelet-mediated delivery of lymphocytes to high endothelial venules.Members of the selectin superfamily have the same domain structure: an N-terminal lectin domain followed by an EGF repeat; a variable number (between 2 and 9) of complement regulatory elements; a single trans-membrane region; and a short cytoplasmic anchor. Some studies have found distinct carbohydrate structures on leukocytes that are adhered to byselectins, suggesting that selectins are involved in the selective trafficking of blood-borne components of the immune system.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR016348 L-selectin L-selectin Family

7 Contains

Id Name Short Name Type
IPR016187 C-type lectin fold C-type_lectin_fold Domain
IPR013032 EGF-like, conserved site EGF-like_CS Conserved_site
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR001304 C-type lectin C-type_lectin Domain
IPR000436 Sushi/SCR/CCP domain Sushi_SCR_CCP_dom Domain
IPR016186 C-type lectin-like C-type_lectin-like Domain
IPR018378 C-type lectin, conserved site C-type_lectin_CS Conserved_site

0 Found In

0 Parent Features

1 Publications

First Author Title Year Journal Volume Pages
Larigan JD Characterization of cDNA and genomic sequences encoding rabbit ELAM-1: conservation of structure and functional interactions with leukocytes. 1992 DNA Cell Biol 11 149-62

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)