InterPro : IPR015815

Name  Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type Short Name  HIBADH-type
Type  Family Description  This entry contains related reductases/dehydrogenases:3-hydroxyisobutyrate dehydrogenase (HIBADH) () catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate []. In eukaryotes, it is a homodimeric mitochondrial protein involved in valine catabolism. In Pseudomonas aeruginosa[](gene mmsB), it is involved in the distal valine metabolic pathway.2-hydroxy-3-oxopropionate reductase () catalyses the NAP(P)H dependent reduction of 2-hydroxy-3-oxopropionate (tartronate semialdehyde) to D-glycerate. 2-(hydroxymethyl)glutarate dehydrogenase () catalyses the conversion of 2-formylglutarate to (S)-2-hydroxymethylglutarate [].Putative oxidoreductase GLYR1, also known as 3-hydroxyisobutyrate dehydrogenase-like protein or nuclear protein NP60, which regulates p38 MAP kinase activity [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



3 Child Features

Id Name Short Name Type
IPR011548 3-hydroxyisobutyrate dehydrogenase IsoBut3OH_DH Family
IPR006398 2-hydroxy-3-oxopropionate reductase Tartro_sem_red Family
IPR004849 6-phosphogluconate dehydrogenase-related protein 6DGDH-related Family

3 Contains

Id Name Short Name Type
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 6PGDH_NADP-bd Domain
IPR013328 Dehydrogenase, multihelical DH_multihelical Domain
IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site 3-OH-isobutyrate_DH-rel_CS Conserved_site

0 Found In

0 Parent Features

4 Publications

First Author Title Year Journal Volume Pages
Rougraff PM Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases. 1989 J Biol Chem 264 5899-903
Steele MI Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase. 1992 J Biol Chem 267 13585-92
Reitz S Structural and kinetic properties of a beta-hydroxyacid dehydrogenase involved in nicotinate fermentation. 2008 J Mol Biol 382 802-11
Fu J Nuclear protein NP60 regulates p38 MAPK activity. 2006 J Cell Sci 119 115-23

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)