InterPro : IPR018479

Name  Monopolin complex, subunit Lrs4 Short Name  Lrs4/Mde4
Type  Family Description  Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae(Baker's yeast), that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I []. The orthologous complex in Schizosaccharomyces pombe(Fission yeast) is not required for meiosis I chromosome segregation, but is proposed to play a similar physiological role in clamping microtubule binding sites []. In S. cerevisiae this subunit is called LRS4, and in S. pombe it is known as Mde4 [].

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



0 Child Features

0 Contains

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Tóth A Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i. 2000 Cell 103 1155-68
Rabitsch KP Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. 2003 Dev Cell 4 535-48
Gregan J The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. 2007 Curr Biol 17 1190-200

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)