InterPro : IPR005650

Name  BlaI transcriptional regulatory family Short Name  BlaI_family
Type  Family Description  Proteins in this entry are transcriptional regulators found in a variety of bacteria and a small number of archaea. Many are BlaI/MecI proteins which regulate resistance to penicillins (beta-lactams), though at least one protein () appears to be involved in the regulation of copper homeostasis []. BlaI regulators repress the expression of penicillin-degrading enzymes (penicillinases) until the cell encounters the antiobiotic, at which point repression ceases and penicillinase expression occurs, allowing cell growth []. MecI regulators repress the expression of MecA, a cell-wall biosynthetic enzyme not inhibited by penicillins at clinically achievable concentrations, until the presence of the antibiotic is detected []. At this point repression ends and MecA expression occurs which, together with the switching off of the penicillin-sensitive enzymes, allows the cell to grow despite the presence of antibiotic.

Sequence Features

GO Displayer


InterPro protein domain ID --> Contigs



1 Child Features

Id Name Short Name Type
IPR014071 Copper transport repressor CopY/TcrY Cu_transp_CopY/TcrY Family

1 Contains

Id Name Short Name Type
IPR011991 Winged helix-turn-helix DNA-binding domain WHTH_DNA-bd_dom Domain

0 Found In

0 Parent Features

3 Publications

First Author Title Year Journal Volume Pages
Odermatt A Two trans-acting metalloregulatory proteins controlling expression of the copper-ATPases of Enterococcus hirae. 1995 J Biol Chem 270 4349-54
Melckebeke HV Solution structural study of BlaI: implications for the repression of genes involved in beta-lactam antibiotic resistance. 2003 J Mol Biol 333 711-20
García-Castellanos R Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance. 2003 J Biol Chem 278 39897-905

To cite PlanMine, please refer to the following publication:

Rozanski, A., Moon, H., Brandl, H., Martín-Durán, J. M., Grohme, M., Hüttner, K., Bartscherer, K., Henry, I., & Rink, J. C.
PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity
Nucleic Acids Research, gky1070. doi:10.1093/nar/gky1070 (2018)